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Cat. No.: HY-W674387

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Nec-34i

Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis.

For research use only. We do not sell to patients.

CAS No.: 2212541-00-7
Formula: C₂₁H₁₉N₃O₂S
Molecular Weight:377.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nec-34i Chemical Structure

CAS No.: 2212541-00-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis^[1].

All RIP kinase Isoforms :

In Vitro

Nec-34i (20 μM; 1 h) does not bind to or stabilize recombinant human RIPK1 kinase domain (residues 1-330) in a protein thermal shift assay^[1].
Nec-34i (20 μM; 10 min) does not inhibit the in vitro kinase activity of human RIPK1 kinase domain (residues 1-330) from transfected 293T cells^[1].
Nec-34i (10 μM) does not inhibit TNFα-induced necroptosis in FADD-deficient Jurkat cells or zVAD.fmk-induced necroptosis in L929 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2212541-00-7
Molecular Weight 377.46
Formula C₂₁H₁₉N₃O₂S
SMILES

N#CC1=C(NC(CC1C2=CC=C(C)C=C2)=O)SCC(NC3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meng H, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell discovery. 2021 Jun 01;7(1):41. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
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Nec-34i

All RIP kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Nec-34i Related Classifications

HY-W674387 Related Classifications