2919964-79-5
2919964-79-5
Chemical Structure
RIPK1-IN-14
- CAS No.: 2919964-79-5
- Formula:C25H25F2N3O2
- Molecular Weight:437.48
IUPAC Name: 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8-diazaspiro[4.5]decan-1-one
InChIKey: YATBYSZORSKSPZ-UHFFFAOYSA-N
SMILES: CN1C=CC2=CC=C(C=C21)C(N3CCC4(CCN(C4=O)CC5=CC(F)=CC=C5F)CC3)=O
Biological Activity: RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC50 value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells[1].
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RIPK1-IN-14 | RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC50 value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells. | |||||||||||||||||||||
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References
Keywords
