2. Signaling Pathways
  3. Immunology/Inflammation
  4. Cyclic GMP-AMP Synthase
  5. Cyclic GMP-AMP Synthase Degrader

Cyclic GMP-AMP Synthase Degrader

Cyclic GMP-AMP Synthase Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-172208
    PROTAC cGAS degrader-1
    		Degrader 99.07%
    PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC50 values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis.
  • HY-162967
    MS8588
    		Degrader
    MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity.
  • HY-162966
    MS7829
    		Degrader
    MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits OTUB1 to cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research.