Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10878):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-132657S

Dehydro Felodipine-d₃
Dehydro Felodipine-d₃ is the deuterium labeled Dehydro Felodipine.

HY-118139S

Celecoxib-d₄
Celecoxib-d₄ is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an?analog?of Celecoxib and with the optimal yield of 75%.

HY-W012722BS

4-Methyl-2-oxopentanoic acid-d₇ sodium
4-Methyl-2-oxopentanoic acid-d₇ (α-Ketoisocaproic acid-d₇) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways.

HY-12721S

Clonidine-d₄ hydrochloride
Clonidine-d₄ (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist.

HY-108251S

Methotrexate metabolite-d₃
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.

HY-B0121BS1

Sumatriptan-d₆
Sumatriptan-d₆ is the deuterium labeled Sumatriptan. Sumatriptan is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan can be used for migraine headache research.

HY-132674S

Benzylhydrochlorothiazide-d₅
Benzylhydrochlorothiazide-d₅ is the deuterium labeled Benzylhydrochlorothiazide.

HY-W060131S

Acetanthranil-d₃
Acetanthranil-d₃ is the deuterium labeled Acetanthranil.

HY-B2030S

Propanil-d₅
Propanil-d₅ is the deuterium labeled Propanil. Propanil is a widely used contact herbicide, mainly use in rice production.

HY-141757S

Des-p-fluorobenzyl mosapride-d₅
Des-p-fluorobenzyl mosapride-d₅ is the deuterium labeled Des-p-fluorobenzyl mosapride.

HY-121356S

Carebastine-d₅
Carebastine-d₅ is the deuterium labeled Carebastine. Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor.

HY-15029S1

(±)-Naproxen-d₃-1
(±)-Naproxen-d₃-1 is the deuterium labeled (±)-Naproxen.

HY-79576S

Estrone 3-methyl ether-d₃
Estrone 3-methyl ether-d₃ is the deuterium labeled Estrone 3-methyl ether.

HY-132286S

2-PADQZ-d₈
2-PADQZ-d₈ is the deuterium labeled 2-PADQZ-d₈.

HY-133797S

Cyclobenzaprine N-oxide-d₃
Cyclobenzaprine N-oxide-d₃ is the deuterium labeled Cyclobenzaprine N-oxide.

HY-15025S1

Sildenafil-d₈
Sildenafil-d₈ is the deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 5.22 nM.

HY-132744S

1-Tetratriacontanol-d₄
1-Tetratriacontanol-d₄ is the deuterium labeled 1-Tetratriacontanol.

HY-W020671S

N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide-d₃
N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide-d₃ is the deuterium labeled N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide.

HY-13832S2

Atovaquone-d₅
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia.

HY-B1589S

(±)-Carbinoxamine-d₆
(±)-Carbinoxamine-d₆ is the deuterium labeled (±)-Carbinoxamine (HY-B1589). (±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc.

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