2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipocalin Family
  5. Lipocalin Family Inhibitor

Lipocalin Family Inhibitor

Lipocalin Family Isoform Comparison

Lipocalin Family Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-148364
    ZINC00784494
    		Inhibitor 99.96%
    ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC).
  • HY-143793
    RBP4 inhibitor 1
    		Inhibitor 99.49%
    RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice.
  • HY-182385
    BPN-14136
    		Inhibitor
    BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC50 of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction (IC50 = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease.
  • HY-164959
    ZINC00230567
    		Inhibitor 99.69%
    ZINC00230567 is an inhibitor for Lipocalin-2 (LCN2). ZINC00230567 reduces the colony formation and cell viability of cell SUM149, and exhibits anti-tumor efficacy.
  • HY-185132
    RBP4-IN-2
    		Inhibitor
    RBP4-IN-2 (Compound 14) is a RBP4 inhibitor. RBP4-IN-2 can reduce RBP4 in mouse plasma by more than 50%. RBP4-IN-2 can be used to study diseases where excessive lipofuscin accumulates in the retina.
  • HY-147366
    RBP4 ligand-1
    		Inhibitor
    RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4-TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively.
  • HY-185133
    RBP4-IN-3
    		Inhibitor
    RBP4-IN-3 (Compound 38) is a retinol-binding protein 4 (RBP4) inhibitor. RBP4-IN-3 can be used in studies related to cardiovascular diseases and obesity.