mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
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mAChR Inhibitors
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mAChR Agonists
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mAChR Antagonists
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mAChR Activators
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mAChR Modulators
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mAChR Inducer
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mAChR Controls
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mAChR Ligands
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mAChR Related Products (721)
Related Products (721)
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Antibodies (2)
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mAChR Isoform Comparison
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(1R,3S-)Solifenacin-d5 hydrochloride
0 ImagesCat. No.: HY-135329SCAS No.: 1217810-85-9(1R,3S-)Solifenacin-d5 hydrochloride is the deuterium labeled Solifenacin hydrochloride. Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is a muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
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Pirmenol hydrochloride (Standard)
0 ImagesCat. No.: HY-100795ARCAS No.: 61477-94-9Synonyms: (±)-Pirmenol hydrochloride (Standard); CI-845 (Standard)Pirmenol (hydrochloride) (Standard) is the analytical standard of Pirmenol (hydrochloride) (HY-100795A). This product is intended for research and analytical applications. Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.
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Flavoxate-d4 (hydrochloride)
0 ImagesCat. No.: HY-B0549ASCAS No.: 1189678-43-0Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.
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NPC-14695
0 ImagesCat. No.: HY-183932CAS No.: 146561-59-3NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle.
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Pilocarpine Hydrochloride (Standard)
0 ImagesPilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
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N-Desethyloxybutynin hydrochloride
0 ImagesCat. No.: HY-W739521CAS No.: 81039-77-2N-Desethyloxybutynin hydrochloride is an active metabolite of Oxybutynin. N-Desethyloxybutynin hydrochloride binds to mAChRs in isolated? human bladder and human parotid gland with pKi values of 8.2 and 8.7, respectively.
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Phenglutarimid hydrochloride
0 ImagesCat. No.: HY-U00001ACAS No.: 1674-96-0Synonyms: Ciba 10870 hydrochloride; Phenglutarimide hydrochloridePhenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
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YM-58790 (Standard)
0 ImagesCat. No.: HY-101679RCAS No.: 214558-72-2YM-58790 (Standard) is the analytical standard of YM-58790 (HY-101679). This product is intended for research and analytical applications. YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with Ki values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats.
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(R)-Hydroxytolterodine-d14
0 ImagesCat. No.: HY-76569S1CAS No.: 1191280-58-6Synonyms: PNU-200577-d14; 5-Hydroxymethyl Tolterodine-d14(R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
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WIN 62,577
0 ImagesCat. No.: HY-118356CAS No.: 144177-32-2WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
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Dicyclomine hydrochloride (Standard)
0 ImagesDicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
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Irsogladine (Standard)
0 ImagesSynonyms: Dicloguamine (Standard)Irsogladine (Standard) is the analytical standard of Irsogladine. This product is intended for research and analytical applications. 0
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Cyclodrine hydrochloride
0 ImagesCat. No.: HY-U00139CAS No.: 78853-39-1
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CDD0102
0 ImagesCat. No.: HY-U00230CAS No.: 146422-58-4Synonyms: CDD0102ACDD0102 is a potent M1 Muscarinic receptor agonist.
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Tematropium
0 ImagesSynonyms: CDDD3602; HGP6Tematropium (CDDD3602) is a soft anticholinergics.
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BTM-1086
0 ImagesCat. No.: HY-U00406CAS No.: 72293-17-5BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.
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YM-46303
0 ImagesCat. No.: HY-U00104CAS No.: 171722-81-9YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.
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Benzamide Derivative 1
0 ImagesCat. No.: HY-U00415CAS No.: 108226-05-7Benzamide Derivative 1 is a benzamide derivative from patent EP0213775A1, compound 18. Benzamide Derivative 1 may be useful in treatment of gastrointestinal disorders.
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Timepidium bromide
0 ImagesCat. No.: HY-U00184CAS No.: 35035-05-3Synonyms: Sesden; SA504Timepidium bromide (Sesden; SA504) is an anticholinergic agent.
