mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
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mAChR Inhibitors
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mAChR Agonists
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mAChR Antagonists
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mAChR Activators
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mAChR Modulators
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mAChR Inducer
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mAChR Controls
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mAChR Ligands
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mAChR Related Products (721)
Related Products (721)
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Antibodies (2)
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mAChR Isoform Comparison
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Siltenzepine
0 ImagesCat. No.: HY-101694CAS No.: 98374-54-0Synonyms: AWD 26-06 free baseSiltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po).
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Elucaine
0 ImagesCat. No.: HY-101743CAS No.: 25314-87-8Elucaine is a muscarinic acetylcholine receptor antagonist with anti-ulcerative activity.
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Solifenacin (Standard)
0 ImagesSynonyms: YM905 free base (Standard)Solifenacin (Standard) is the analytical standard of Solifenacin. This product is intended for research and analytical applications. Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
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Sofpironium bromide (Standard)
0 ImagesCat. No.: HY-109013RCAS No.: 1628106-94-4Synonyms: BBI 4000 (Standard)Sofpironium bromide (Standard) is the analytical standard of Sofpironium (bromide) (HY-109013). This product is intended for research and analytical applications. Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
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Muscarine tosylate
0 ImagesCat. No.: HY-121404BCAS No.: 82083-43-0Synonyms: (+)-Muscarine tosylateMuscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system.
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BIBN-99
0 ImagesBIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury.
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Xanomeline (Standard)
0 ImagesSynonyms: LY-246708 (Standard)Xanomeline (Standard) is the analytical standard of Xanomeline. This product is intended for research and analytical applications. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.
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Methapyrilene (Standard)
0 ImagesCat. No.: HY-111130RCAS No.: 91-80-5Methapyrilene (Standard) is the analytical standard of Methapyrilene (HY-111130). This product is intended for research and analytical applications. Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats.
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VU 6008667 (Standard)
0 ImagesCat. No.: HY-101281RCAS No.: 2092923-21-0VU 6008667 (Standard) is the analytical standard of VU 6008667 (HY-101281). This product is intended for research and analytical applications. VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.
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VU 0255035 (Standard)
0 ImagesCat. No.: HY-108234RCAS No.: 1135243-19-4Synonyms: VU 255035 (Standard)VU 0255035 (Standard) is the analytical standard of VU 0255035 (HY-108234). This product is intended for research and analytical applications. VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, ParKinson's disease, and dystonia.
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VU 0365114 (Standard)
0 ImagesCat. No.: HY-107651RCAS No.: 1208222-39-2VU 0365114 (Standard) is the analytical standard of VU 0365114 (HY-107651). This product is intended for research and analytical applications. VU 0365114 is a selective mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM, and >30 μM for M1, M2, M3 and M4 receptors. VU 0365114 increases insulin secretion stimulated by ACh in human β-cells.
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(S)-Oxybutynin hydrochloride
0 ImagesCat. No.: HY-19652ACAS No.: 230949-16-3Synonyms: Esoxybutynin hydrochloride(S)-Oxybutynin (Esoxybutynin) hydrochloride is a potent muscarinic receptor antagonist.
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rel-(-)-Vesamicol
0 ImagesCat. No.: HY-113995ACAS No.: 115362-28-2Synonyms: rel-(-)-AH5183rel-(-)-Vesamicol (rel-(-)-AH5183) is the racemate of (-)-Vesamicol. (-)-Vesamicol is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty.
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(R)-VU 6008667 (Standard)
0 ImagesCat. No.: HY-101281BRCAS No.: 2097818-14-7(R)-VU 6008667 (Standard) is the analytical standard of (R)-VU 6008667 (HY-101281B). This product is intended for research and analytical applications. (R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC50>10 μM).
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Thiochrome (Standard)
0 ImagesThiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.
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Glycopyrrolate (Standard)
0 ImagesSynonyms: Glycopyrronium bromide (Standard); Glycopyrrolate bromide (Standard)Glycopyrrolate (Standard) is the analytical standard of Glycopyrrolate. This product is intended for research and analytical applications. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases.
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Diphenidol-d10 hydrochloride
0 ImagesCat. No.: HY-A0082SSynonyms: Difenidol hydrochloride-d10Diphenidol-d10 (hydrochloride) (Difenidol hydrochloride-d10) is deuterium labeled Diphenidol (hydrochloride). Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea.
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Biperiden (Standard)
0 ImagesCat. No.: HY-13204ARCAS No.: 514-65-8Synonyms: KL 373 (Standard)Biperiden (Standard) is the analytical standard of Biperiden. This product is intended for research and analytical applications. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
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Solifenacin N-oxide
0 ImagesCat. No.: HY-43421CAS No.: 180272-28-0Synonyms: Solifenacin N1-oxideSolifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034).
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Smilagenin (Standard)
0 ImagesCat. No.: HY-106353RCAS No.: 126-18-1Smilagenin (Standard) is the analytical standard of Smilagenin. This product is intended for research and analytical applications. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.
