1135243-19-4
Chemical Structure
VU 0255035
Synonym(s): VU 255035
- CAS No.: 1135243-19-4
- Formula:C18H20N6O3S2
- Molecular Weight:432.52
IUPAC Name: N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide
InChIKey: WXDHQWPQLKGANZ-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=NSN=C21)(NCCC(N3CCN(C4=CC=NC=C4)CC3)=O)=O
Biological Activity: VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, Parkinson's disease, and dystonia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU 0255035 | 99.76% | VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, Parkinson's disease, and dystonia. | ||||||||||||||||||||
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VU 0255035 (Standard) | ≥98% | VU 0255035 (Standard) is the analytical standard of VU 0255035 (HY-108234). This product is intended for research and analytical applications. VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, ParKinson's disease, and dystonia. | ||||||||||||||||||||
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- [1]. Sheffler DJ, et al. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol Pharmacol. 2009 Aug;76(2):356-68. [Content Brief]
- [2]. Grafe EL, et al. Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. J Neurophysiol. 2021 Nov 1;126(5):1622-1634. [Content Brief]
- [3]. Kurowski P, et al. Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats. Neuroscience. 2015 Sep 10;303:474-88. [Content Brief]
Keywords
