2. Signaling Pathways
  3. Neuronal Signaling
  4. Prion Protein
  5. Prion Protein Degrader

Prion Protein Degrader

Prion Protein Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-150286A
    (R)-SM875
    		Degrader
    (R)-SM875 is a degrader targeting the intermediate folding form of prion protein (PrP). (R)-SM875 significantly reduces the PrP level, with an IC50 of 3 μM. (R)-SM875 can be used for the study of prion diseases.
  • HY-150286
    SM875
    		Degrader 98.89%
    SM875 is a cellular prion protein (PrP) degrader (IC50: 7.87 μM). SM875 targets PrP folding intermediates and promotes its degradation through the autophagy-lysosomal pathway. SM875 only acts on nascent, immature PrP molecules and has no effect on mature PrP before synthesis. SM875 can inhibit prion replication and has potential in the study of neurodegenerative diseases (i.e., prion diseases).