2715974-36-8
Chemical Structure
(R)-SM875
- CAS No.: 2715974-36-8
- Formula:C19H16BrN3O3
- Molecular Weight:414.25
InChIKey: BFJSUOGAXIMPQB-CQSZACIVSA-N
SMILES: O=C1NC2=C(C=NN2C3=CC=C(C=C3)Br)[C@@H](C4=CC(OC)=C(C=C4)O)C1
Biological Activity: (R)-SM875 is a cellular prion protein (PrP) degrader with an IC50 of 3 μM in HEK293 cells. (R)-SM875 interacts with PrP folding intermediates, binds to a binding pocket unique to FI-PrP, inhibits PrPC maturation, blocks prion replication, and induces cytotoxicity, autophagy, PrPC aggregation, as well as lysosome-dependent autophagy-mediated post-translational degradation of PrPC, without altering the mRNA level of PrPC. (R)-SM875 can be used in research related to prion diseases[1][2].
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(R)-SM875 | (R)-SM875 is a cellular prion protein (PrP) degrader with an IC50 of 3 μM in HEK293 cells. (R)-SM875 interacts with PrP folding intermediates, binds to a binding pocket unique to FI-PrP, inhibits PrPC maturation, blocks prion replication, and induces cytotoxicity, autophagy, PrPC aggregation, as well as lysosome-dependent autophagy-mediated post-translational degradation of PrPC, without altering the mRNA level of PrPC. (R)-SM875 can be used in research related to prion diseases. | |||||||||||||||||||||
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References
- [1]. Innocenti N, et al. Enantiomers of the prion protein degrader SM875: Production and configurational assignment, in silico analysis and in vitro evaluation. Bioorganic chemistry. 2025 Jul 01;161:108489. [Content Brief]
- [2]. Biasini E. Small molecules inducing the degradation of the cellular prion protein [Internet]. 2021 Sep 30 [cited 2026 Sep 1]. WO2021191883A1.
