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Trehalose 6-behenate 

Cat. No.: HY-101871
Handling Instructions

Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.

For research use only. We do not sell to patients.

Trehalose 6-behenate Chemical Structure

Trehalose 6-behenate Chemical Structure

CAS No. : 66755-19-9

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.

IC50 & Target

Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5041 mL 7.5204 mL 15.0408 mL
5 mM 0.3008 mL 1.5041 mL 3.0082 mL
10 mM 0.1504 mL 0.7520 mL 1.5041 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

664.86

Formula

C₃₄H₆₄O₁₂

CAS No.

66755-19-9

SMILES

O[[email protected]]([[email protected]@H](O)[[email protected]@H]1O)[[email protected]](O[[email protected]@H]1COC(CCCCCCCCCCCCCCCCCCCCC)=O)O[[email protected]@]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]2O)O)([H])O[[email protected]@H]2CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Trehalose 6-behenate
Cat. No.:
HY-101871
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Trehalose 6-behenate

Cat. No.: HY-101871