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Cat. No.: HY-185830

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ADC Control Human IgG1-vcMMAE (DAR8)

ADC Control Human IgG1-vcMMAE (DAR8) is an antibody-drug conjugate (ADCs), serving as an isotype control for ADC human IgG1-vcMMAE, and inhibits tubulin polymerization. The antibody moiety of ADC Control Human IgG1-vcMMAE (DAR8) is Human IgG1 kappa, Isotype Control (HY-P99001), while the cytotoxic payload and linker moiety are VcMMAE (HY-15575). ADC Control Human IgG1-vcMMAE can be used in cancer-related research.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

ADC Control Human IgG1-vcMMAE (DAR8) Chemical Structure

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Biological Activity

Description

In Vitro

ADC Control Human IgG1-vcMMAE (DAR8) (nonbinding control ADC) (1 μg/mL; 120 h) does not induce cytotoxicity or bystander cytotoxic activity in co-culture systems of L540cy/Ramos cells or Karpas299/Ramos cells^[1].
ADC Control Human IgG1-vcMMAE (DAR8) lacks specific binding ability to cell surface antigens. It enters cells only via weak non-specific adsorption. The vc linker can be cleaved by lysosomal cathepsins to release free MMAE, which is a microtubule polymerization inhibitor with membrane permeability and can exert a bystander killing effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

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[ADC Control Human IgG1-vcMMAE (DAR8)]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Okeley NM, et al. Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010 Feb 01;16(3):888-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ADC Control Human IgG1-vcMMAE (DAR8)

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ADC Control Human IgG1-vcMMAE (DAR8)

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ADC Control Human IgG1-vcMMAE (DAR8) Related Classifications

HY-185830 Related Classifications