Androgen receptor antagonist 5
Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2586195-28-8
- Formula: C21H15F4N5O3S
- Molecular Weight:493.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 6.17 μM (AR)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
94.3 μM
Compound: 42f
|
Antiproliferative activity against human DU-145 cells assessed as reduction in cel viability after 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as reduction in cel viability after 72 hrs by MTT assay
|
[PMID: 32169785] |
| LNCaP | IC50 |
14.8 μM
Compound: 42f
|
Antiproliferative activity against human LNCaP cells assessed as reduction in cel viability after 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cel viability after 72 hrs by MTT assay
|
[PMID: 32169785] |
Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2586195-28-8
-
Molecular Weight 493.43
-
Formula C21H15F4N5O3S
-
SMILES
CCOC(NC1=CC2=C(CC3C(N(C(N3C2)=S)C4=CC(C(F)(F)F)=C(N=C4)C#N)=O)C=C1F)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Androgen receptor antagonist 5 Related Classifications
HY-146494 Related Classifications
Powered by Bioz