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Cat. No.: HY-N8488

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Anhydro-6-epiophiobolin A

Anhydro-6-epiophiobolin A, an analog of Ophiobolin A, is a potent inhibitor of photosynthesis (I₅₀s of 6.1 and 1 mM for photosynthesis in Chlorella and Spinach, respectively).

For research use only. We do not sell to patients.

CAS No.: 90411-20-4
Formula: C₂₅H₃₄O₃
Molecular Weight:382.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anhydro-6-epiophiobolin A Chemical Structure

CAS No.: 90411-20-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-B0850S

Difenoconazole-d6 hydrochloride

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Anhydro-6-epiophiobolin A, an analog of Ophiobolin A, is a potent inhibitor of photosynthesis (I₅₀s of 6.1 and 1 mM for photosynthesis in Chlorella and Spinach, respectively)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	9 μM Compound: 9	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 26341136]
A549	IC₅₀	>40 μM Compound: 10	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 31573805]
HepG2	IC₅₀	>40 μM Compound: 10	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 31573805]
HepG2	IC₅₀	47.1 μM Compound: 3	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23668986]
Hs 683	GI₅₀	8 μM Compound: 9	Antiproliferative activity against human Hs683 cells by MTT assay Antiproliferative activity against human Hs683 cells by MTT assay	[PMID: 26341136]
K562	IC₅₀	35.6 μM Compound: 3	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23668986]
MCF7	GI₅₀	10 μM Compound: 9	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 26341136]
MDA-MB-231	IC₅₀	>40 μM Compound: 10	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 31573805]
RAW264.7	IC₅₀	5.1 μM Compound: 10	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay	[PMID: 31573805]
SK-MEL-28	GI₅₀	8 μM Compound: 9	Antiproliferative activity against human SK-MEL-28 cells by MTT assay Antiproliferative activity against human SK-MEL-28 cells by MTT assay	[PMID: 26341136]
SW1990	IC₅₀	>40 μM Compound: 10	Cytotoxicity against human SW1990 cells by MTT assay Cytotoxicity against human SW1990 cells by MTT assay	[PMID: 31573805]
U-373MG ATCC	GI₅₀	18 μM Compound: 9	Antiproliferative activity against human U373 cells by MTT assay Antiproliferative activity against human U373 cells by MTT assay	[PMID: 26341136]

Chemical Information

CAS No. 90411-20-4
Molecular Weight 382.54
Formula C₂₅H₃₄O₃
SMILES

C[C@@H]1[C@]2(O[C@H](C1)/C=C(C)\C)[C@@]3([H])[C@](CC2)(C[C@@]4([H])[C@](C(C=C4C)=O)([H])/C(C=O)=C\C3)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Helminthosporium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin-Myeon Kim, et al. Isolation of Ophiobolin A and Its Analogs as Inhibitors to Photosynthesis, Agricultural and Biological Chemistry, 48:3, 803-805.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Anhydro-6-epiophiobolin A

Difenoconazole-d6 hydrochloride