Anti-Chikungunya virus E2 Antibody (CHK-265)

Cat. No.: HY-P990825 Purity: 95%: Data Sheet
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Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to Chikungunya virus E2. Anti-Chikungunya virus E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV).

For research use only. We do not sell to patients.

Anti-Chikungunya virus E2 Antibody (CHK-265) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Chikungunya virus E2 Antibody (CHK-265) Featured Recommendations:

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Description

Isotype

Mouse IgG2c

Recommend Isotype Controls

Mouse IgG2c kappa, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

B domain of the E2 glycoprotein of chikungunya virus

In Vitro

Anti-Chikungunya virus E2 Antibody (CHK-265) (0.001-10 μg/mL, 19 h) neutralizes alphaviruses that are closely (ONNV) or distantly (MAYV, RRV, and SFV) related to CHIKV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Chikungunya virus E2 Antibody (CHK-265) (100 μg, i.p., 1 day prior to infection) protect against alphavirus disease in CHIKV/MAYV/ONNV infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CHIKV/MAYV/ONNV infected mice models^[1]
Dosage:	100 μg
Administration:	Intraperitoneally injection, 1 day prior to infection
Result:	Reduced ankle joint swelling. Reduced spread to the contralateral ankle joint. Decreased viral burden.

Accession

ADG95913

Application

Viral entry and egress inhibition

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Chikungunya virus E2 Antibody (CHK-265)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95%

Select Batch:

Data Sheet (259 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Fox JM, et al. Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. Cell. 2015 Nov 19;163(5):1095-1107. [Content Brief]

Anti-Chikungunya virus E2 Antibody (CHK-265) Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Chikungunya virus E2 Antibody (CHK-265)FlavivirusCHIKVChikungunya virusAlphavirusesMayaroO’nyong’nyong virusInhibitorinhibitorinhibit

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