Anti-Mouse CD205 Antibody (NLDC-145)
Based on 1 Customer Validation
Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes.
For research use only. We do not sell to patients.
- Purity: 95%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
CD205
Anti-Mouse CD205 Antibody (NLDC-145) (complex composed of the extracellular domain of HER2/neu and the NLDC-145 antibody) (50 μg, intramuscular injection, at days-21 and -7) inhibits tumor growth and increases survival rate in D2F2/E2 tumor mice models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:D2F2/E2 tumor mice models[2]
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Dosage:50 μg
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Administration:Intramuscularly injection, at days -21 and -7
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Result:Showed slow tumor growth.
Increased survival rate.
Showed higher percentage of CD4+ and CD8+ T cells producing IFN-γ and TNF-α.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo antigen-targeting to DEC-205; in vitro antigen-targeting to DEC-205; Immunohistochemistry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD205 Antibody (NLDC-145)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Wadwa M, et al. Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice. Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. [Content Brief]
[2]. Cao J, et al. DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. BMC Immunol. 2013 Aug 14;14:39. [Content Brief]
[3]. Schloss J, et al. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons. 2019 Jun 26;3(6):236-253. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD205 Antibody (NLDC-145) Related Classifications
HY-P990284 Related Classifications
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