Anti-Mouse CD205 Antibody (NLDC-145)

Art. -Nr.: HY-P990284 Reinheit: 95%: Data Sheet
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Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Anti-Mouse CD205 Antibody (NLDC-145) Chemische Struktur

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Anti-Mouse CD205 Antibody (NLDC-145) Spezialitätsempfehlungen:

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD205

In Vitro

Anti-Mouse CD205 Antibody (NLDC-145) (Ins2 cDNA in frame with the C terminus of the H chain of an NLDC-145) binds to insulin polyclonal Ab^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD205 Antibody (NLDC-145) (1 μg, i.p., at days -2 and -1) reduces inflammation in conjugation of the HA_110-120 peptide in in colitis VILLIN-HA transgenic mice transferred with CD4⁺Foxp3⁻ T cells^[1].
Anti-Mouse CD205 Antibody (NLDC-145) (complex composed of the extracellular domain of HER2/neu and the NLDC-145 antibody) (50 μg, intramuscular injection, at days-21 and -7) inhibits tumor growth and increases survival rate in D2F2/E2 tumor mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	D2F2/E2 tumor mice models^[2]
Dosage:	50 μg
Administration:	Intramuscularly injection, at days -21 and -7
Result:	Showed slow tumor growth. Increased survival rate. Showed higher percentage of CD4⁺ and CD8⁺ T cells producing IFN-γ and TNF-α.

Gene ID

17076 [NCBI]

Accession

Q60767

Application

in vivo antigen-targeting to DEC-205; in vitro antigen-targeting to DEC-205; Immunohistochemistry

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molekulargewicht

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD205 Antibody (NLDC-145)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Purity: 95%

Select Batch:

Data Sheet (261 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Wadwa M, et al. Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice. Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. [Content Brief]

[2]. Cao J, et al. DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. BMC Immunol. 2013 Aug 14;14:39. [Content Brief]

[3]. Schloss J, et al. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons. 2019 Jun 26;3(6):236-253. [Content Brief]

Anti-Mouse CD205 Antibody (NLDC-145) Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD205 Antibody (NLDC-145)C-type Lectin-like Receptors (CTLRs)CD205DEC-205ColitisD2F2/E2DiabetesVILLIN-HAInhibitorinhibitorinhibit

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