Anti-Mouse CD48 Antibody (HM48-1)
Based on 1 Customer Validation
Anti-Mouse CD48 Antibody (HM48-1) is an Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD48. Anti-Mouse CD48 Antibody (HM48-1) can block block the CD48/CD2 and CD48/CD244 interactions. Anti-Mouse CD48 Antibody (HM48-1) can be used for the researches of cancer, inflammation and immunology, such as myeloma and experimental autoimmune encephalomyelitis.
For research use only. We do not sell to patients.
- Purity: 97.738%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
CD48
In Vitro
In Vivo
Anti-Mouse CD48 Antibody (HM48-1) (200 μg, i.p., at days 6, 9 and 12) attenuates EAE in experimental autoimmune encephalomyelitis (EAE) mice models[2].
Anti-Mouse CD48 Antibody (HM48-1) (300 μg/dose, i.p., at days -1 and 2) reduces the numbers of peripheral blood (PB) leukocytes and PB lymphocytes in mice with engraftment of congenic marrow[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Experimental autoimmune encephalomyelitis (EAE) mice models[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, at days 6, 9 and 12
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Result:Delayed onset and diminished severity of EAE.
Revealed few lesions and CD4+ T cells in the CNS.
Reduced IFN-γ, TNF-α and IL-17A levels.
Reduced 2D2 CD4+ T cells in the spleen, blood and LNs and reduced 2D2 CD4+ Teff numbers and proliferation.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo CD48 blockade; in vitro CD48 blocking
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD48 Antibody (HM48-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. McArdel SL, et al. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. J Immunol. 2016 Oct 15;197(8):3038-3048. [Content Brief]
[2]. McArdel SL, et al. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. J Immunol. 2016 Oct 15;197(8):3038-3048 [Content Brief]
[3]. lazar BR, et al. A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation. Blood. 1998 Dec 1;92(11):4453-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD48 Antibody (HM48-1) Related Classifications
HY-P990266 Related Classifications
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