Anti-Mouse CD48 Antibody (HM48-1)

Cat. No.: HY-P990266 Purity: 97.738%: Data Sheet
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Anti-Mouse CD48 Antibody (HM48-1) is an Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD48. Anti-Mouse CD48 Antibody (HM48-1) can block block the CD48/CD2 and CD48/CD244 interactions. Anti-Mouse CD48 Antibody (HM48-1) can be used for the researches of cancer, inflammation and immunology, such as myeloma and experimental autoimmune encephalomyelitis.

For research use only. We do not sell to patients.

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Armenian hamster IgG

Recommend Isotype Controls

Polyclonal Armenian hamster IgG, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD48

In Vitro

Anti-Mouse CD48 Antibody (HM48-1) (20 μg/mL, 30 mins) reduces the proportion of CD48⁺ splenocytes and CD48^high BM cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD48 Antibody (HM48-1) (200 μg, i.p., at days 12, 14, 19, 21, 26, and 28) blocks CD48 and fails to have any impact on the elimination of myeloma in mice^[1].
Anti-Mouse CD48 Antibody (HM48-1) (200 μg, i.p., at days 6, 9 and 12) attenuates EAE in experimental autoimmune encephalomyelitis (EAE) mice models^[2].
Anti-Mouse CD48 Antibody (HM48-1) (300 μg/dose, i.p., at days -1 and 2) reduces the numbers of peripheral blood (PB) leukocytes and PB lymphocytes in mice with engraftment of congenic marrow^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Experimental autoimmune encephalomyelitis (EAE) mice models^[1]
Dosage:	200 μg
Administration:	Intraperitoneally injection, at days 6, 9 and 12
Result:	Delayed onset and diminished severity of EAE. Revealed few lesions and CD4⁺ T cells in the CNS. Reduced IFN-γ, TNF-α and IL-17A levels. Reduced 2D2 CD4⁺ T cells in the spleen, blood and LNs and reduced 2D2 CD4⁺ Teff numbers and proliferation.

Gene ID

12506 [NCBI]

Accession

Q18PH8

Application

in vivo CD48 blockade; in vitro CD48 blocking

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD48 Antibody (HM48-1)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

Product Image

Purity & Documentation

Purity: 97.738%

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Data Sheet (261 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (85 KB) SEC-HPLC (159 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. McArdel SL, et al. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. J Immunol. 2016 Oct 15;197(8):3038-3048. [Content Brief]

[2]. McArdel SL, et al. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. J Immunol. 2016 Oct 15;197(8):3038-3048 [Content Brief]

[3]. lazar BR, et al. A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation. Blood. 1998 Dec 1;92(11):4453-63. [Content Brief]

Anti-Mouse CD48 Antibody (HM48-1) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD48 Antibody (HM48-1)Transmembrane GlycoproteinCD48LeukocytesLymphocytesMyelomaExperimental autoimmune encephalomyelitisInhibitorinhibitorinhibit

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