Anti-MRSA agent 45

Anti-MRSA agent 45 (Compound A13) (16-18 h) potently inhibits the growth of S. aureus ATCC 29213 (MIC = 0.008 μg/mL). It also inhibits clinical S. aureus isolates (MICs = 0.016-0.063 μg/mL), MRSA-1 and MRSA-2 (MIC = 0.016 μg/mL), as well as other ESKAPE strains, with MIC values ranging from 0.063 to 8 μg/mL for the latter^[1].
Anti-MRSA agent 45 (0.008-0.125 μg/mL; 0-24 h) completely inhibits the growth of MRSA-2 within 24 h of incubation at concentrations ≥ 0.016 μg/mL^[1].
Anti-MRSA agent 45 (0.016-2 μg/mL; 0-24 h) exhibits rapid, concentration-dependent bactericidal activity against MRSA-2, reducing bacterial counts by up to 6 log₁₀ CFU/mL within 24 h^[1].
Anti-MRSA agent 45 (0.002-0.032 μg/mL; 24 h) potently inhibits biofilm formation by MRSA-2, with nearly complete inhibition at the concentration of 1×MIC (0.016 μg/mL)^[1].
Anti-MRSA agent 45 (0.25-4 μg/mL; 24 h) eradicates preformed MRSA-2 biofilms, with a maximum eradication rate of approximately 60% at the concentration of 4 μg/mL^[1].
Anti-MRSA agent 45 (1-4 μg/mL; 1 h) disrupts the membrane morphology of MRSA-2 in a concentration-dependent manner, causing severe damage at concentrations ≥ 2 μg/mL^[1].
Anti-MRSA agent 45 (1-4 μg/mL; 1 h) disrupts the cell membrane integrity of MRSA-2, increases PI uptake and induces cell death at concentrations ≥ 1 μg/mL^[1].
Anti-MRSA agent 45 (1-8 μg/mL; 0-1 h) disrupts the membrane polarization of MRSA-2 in a time- and concentration-dependent manner^[1].
Anti-MRSA agent 45 (1-8 μg/mL; 0-1 h) increases the membrane permeability of MRSA-2 in a concentration-dependent manner, and significant PI uptake is observed at concentrations ≥ 1 μg/mL^[1].
Anti-MRSA agent 45 (0.5-64 μg/mL; 1 h) shows no significant hemolytic activity against sheep red blood cells, with an HC₅₀ > 64 μg/mL^[1].
Anti-MRSA agent 45 (24 h) exhibits moderate cytotoxicity against the CaCo-2 (IC₅₀ = 5.347 μg/mL), 293-T (IC₅₀ = 4.704 μg/mL), AML-12 (IC₅₀ = 4.621 μg/mL) and HepG2 (IC₅₀ = 4.092 μg/mL) cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.