2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 127

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent.

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Antibacterial agent 127

Antibacterial agent 127 Chemische Struktur

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Antibacterial agent 127 Related Antibodies

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Beschreibung

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent[1].

IC50 & Target

Bacterial[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
> 100 μM
Compound: 23
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 36462445]
In Vitro

Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) shows antibacterial activity with MICs of 0.063, 0.063, 0.063, 0.25, 32 and 64 μg/mL against MSSA ATCC29213, MSSA ATCC25923, MRSAb, MRSEb, E.coli ATCC25922 and S.pullorum, respectively. And shows low cytotoxicity to RAW 264.7 cells (IC50＞100 μM)[1].
Antibacterial agent 127 shows good metabolic stability (t1/2 = 3.25 min in rat liver microsomes)[1].
Antibacterial agent 127 exhibits moderate inhibition effect on CYP3A4 (Midazolam) and CYP3A4 (Testosterone), with IC50 values of 2.64 and 1.94 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 127 Related Antibodies
In Vivo

Antibacterial agent 127 (Compound 23) (50 mg/kg; i.p.; single dose) inhibits MRSA effectively in a mouse thigh infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice, neutropenic mouse thigh infection model[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, single dose
Result: Reduced bacteria count with a value of 1.84 log10 CFU/mL in comparison with vehicle control group.
Molekulargewicht

527.68

Formel

C28H37N3O5S
SMILES

C[C@]([C@@H](O)[C@@H]1C)(C[C@@H](OC(CSC(N2)=NC3=C(C=CN3)C2=O)=O)[C@@]4(C)[C@@]5([H])[C@]1(CCC5=O)CC[C@H]4C)C=C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Antibacterial agent 127 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 127Antibacterial agent127Antibacterial agent-127BacterialMSSAMRSAbMRSEbE.coliS.pullorumInhibitorinhibitorinhibit

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