Antibacterial agent 143

Art. -Nr.: HY-153576 Reinheit: 91.85%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Antibacterial agent 143 (Compound 5a) is an antibacterial agent with MICs of 25, 25, 50 and 50 μg/mL against B. subtilis ATCC6633, S. aureus ATCC6538, P. aeruginosa ATCC13525 and E. coli ATCC35218, respectively.

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Antibacterial agent 143 Chemische Struktur

CAS. Nr. : 299405-68-8

Größe	Verfügbarkeit	Menge
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Molekulargewicht

373.27

Formel

C₁₇H₁₃BrN₂OS

CAS. Nr.

299405-68-8

Appearance

Solid

Color

White to yellow

SMILES

O=C(CC1=CC=CC=C1)NC2=NC(C3=CC=C(Br)C=C3)=CS2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (267.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6790 mL	13.3951 mL	26.7903 mL
5 mM	0.5358 mL	2.6790 mL	5.3581 mL
10 mM	0.2679 mL	1.3395 mL	2.6790 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 91.85%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (246 KB) HNMR (265 KB) RP-HPLC (235 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Li JR, et al. Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. Eur J Med Chem. 2014 Mar 21;75:438-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6790 mL	13.3951 mL	26.7903 mL	66.9756 mL
	5 mM	0.5358 mL	2.6790 mL	5.3581 mL	13.3951 mL
	10 mM	0.2679 mL	1.3395 mL	2.6790 mL	6.6976 mL
	15 mM	0.1786 mL	0.8930 mL	1.7860 mL	4.4650 mL
	20 mM	0.1340 mL	0.6698 mL	1.3395 mL	3.3488 mL
	25 mM	0.1072 mL	0.5358 mL	1.0716 mL	2.6790 mL
	30 mM	0.0893 mL	0.4465 mL	0.8930 mL	2.2325 mL
	40 mM	0.0670 mL	0.3349 mL	0.6698 mL	1.6744 mL
	50 mM	0.0536 mL	0.2679 mL	0.5358 mL	1.3395 mL
	60 mM	0.0447 mL	0.2233 mL	0.4465 mL	1.1163 mL
	80 mM	0.0335 mL	0.1674 mL	0.3349 mL	0.8372 mL
	100 mM	0.0268 mL	0.1340 mL	0.2679 mL	0.6698 mL