2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 156

Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains).

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Antibacterial agent 156

Antibacterial agent 156 Chemical Structure

CAS No. : 3032400-44-2

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Antibacterial agent 156 Related Antibodies

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Description

Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains)[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
53.4 μg/mL
Compound: 57
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by XTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by XTT assay
[PMID: 37732641]
THP-1 IC50
> 128 μg/mL
Compound: 57
Cytotoxicity against human THP-1 cells assessed as increase in LDH release incubate for 24 hrs by trypan-blue staining based analysis
Cytotoxicity against human THP-1 cells assessed as increase in LDH release incubate for 24 hrs by trypan-blue staining based analysis
[PMID: 37732641]
Masse moléculaire

341.32

Formule

C16H15N5O4
CAS No.
SMILES

O=[N+](C1=CN=C(C2=NC(C3=CC=C(OC4CCCC4)C=C3)=NO2)N1)[O-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Antibacterial agent 156 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 1563032400-44-2Antibacterial agent156Antibacterial agent-156BacterialMIMIC50 (101 strains)MIC90(101 strains)bactericidalcell-wall synthesisInhibitorinhibitorinhibit

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