ACOX2 Antibody
(Synonyms: Peroxisomal acyl-coenzyme A oxidase 2, Trihydroxycoprostanoyl-CoA oxidase, THCA-CoA oxidase, THCCox, ACOX2)ACOX2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ACOX2.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ELISA
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS(pH7.4) containing 50% glycerol, and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:5000-20000 |
Product Details
ACOX2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ACOX2.
-
Host Rabbit
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 77 kDa
OMIM: 601641
A synthesized peptide derived from human ACOX2.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS(pH7.4) containing 50% glycerol, and 0.02% sodium azide.
-
Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
-
Shipping
Shipping with blue ice.
Background
-
Function
ACOX2 is involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs) and bile acids intermediates. Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product. Oxidizes its substrates in a stereospecific way and can only desaturate isomers carrying (2S)-methyl groups (By similarity). In brown adipose tissue peroxisomes, mediates beta-oxidation of monomethyl branched-chain fatty acids with iso configuration (mmBCFAs) as part of a substrate synthesis and oxidation cycle fueled by FASN-dependent de novo mmBCFA synthesis. The mmBCFA catabolism is coupled to AMPK activation and mitochondrial ATP production as a thermogenic adaptation mechanism to maintain the body temperature in cold environment (By similarity). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3. In the liver, mediates side-chain beta-oxidation of C27 bile acyl-CoA intermediates carrying a (25S)-methyl group to yield 24,25-trans unsaturated derivatives as part of peroxisomal bile acid synthesis pathway. Can oxidize straight-chain fatty acyl CoAs such as C10-CoA and C16-CoA with low efficiency[1][2].
-
Subcellular Localization
Peroxisome
-
Expression
Tissue_Specificity: Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney (at protein level). -
Isoforms & Post-Translational Modification
ACOX2 has an amino acid length of 681, molecular weight is 76827 Da.ACOX2 的氨基酸个数为 681 个，分子量为 76827 Da。
-
Subunit
Homodimer
-
SwissProt ID
-
Synonyms
Peroxisomal acyl-coenzyme A oxidase 2, Trihydroxycoprostanoyl-CoA oxidase, THCA-CoA oxidase, THCCox, ACOX2
Documentation
Powered by Bioz
