AF647-conjugated CD14 Antibody (M5E2)
(Synonyms: CD14,CD14-AF647,M5E2)AF647-conjugated CD14 Antibody (M5E2) is a Mouse-derived and AF647 conjugated monoclonal antibody, targeting to CD14.
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Host:
Mouse
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Isotype:
Mouse IgG2a,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
AF647
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Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD14 is an important innate immune pattern recognition receptor, primarily serving as a component of the lipopolysaccharide (LPS) receptor complex. It plays a crucial role in recognizing Gram-negative bacteria and their products, and in activating inflammatory responses. CD14 itself lacks a transmembrane signal transduction structure; therefore, it typically functions as a co-receptor in synergy with TLR4 and MD-2.
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Secreted; Membrane raft; Golgi apparatus
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Expression
Tissue_specificity:Protein levels were detected on macrophages (PubMed: 1698311) . It is strongly expressed on the surface of monocytes and weakly expressed on the surface of granulocytes; it is also expressed in macrophages of most tissues.
Induction:The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced -
Subunit
Interacts with LPS-bound LPB. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4.
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Synonyms
CD14,CD14-AF647,M5E2
Documentation
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