AF700-conjugated CD105 Antibody (43A3)
(Synonyms: CD105,CD105-AF700,43A3)AF700-conjugated CD105 Antibody (43A3) is a Mouse-derived and AF700 conjugated monoclonal antibody, targeting to CD105.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
AF700
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD105 (Endoglin, ENG) is a TGF-β receptor accessory protein primarily expressed on mesenchymal stem cells and activated endothelial cells; it serves as a classic positive marker for the identification of mesenchymal stem cells (MSCs) and is a key target in research concerning angiogenesis, tumor neovascularization, and fibrosis.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Detected in umbilical cord membrane endothelial cells (PubMed: 10625079) . Detected in the placenta (protein level) (PubMed: 1692830) . Detected in endothelial cells (PubMed: 1692830) . -
Isoforms & Post-Translational Modification
CD105 has 2 isomers: P17813-1: 70578 Da (predicted); P17813-2: 67542 Da (predicted).
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Subunit
Homodimer; disulfide-linked. Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3. Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with DYNLT4. Interacts with ARRB2
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Synonyms
CD105,CD105-AF700,43A3
Documentation
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