AF700-conjugated CD127 Antibody (A019D5)
(Synonyms: CD127,CD127-AF700,A019D5)AF700-conjugated CD127 Antibody (A019D5) is a Mouse-derived and AF700 conjugated monoclonal antibody, targeting to CD127.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
AF700
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
AF700-conjugated CD127 Antibody (A019D5) is a Mouse-derived and AF700 conjugated monoclonal antibody, targeting to CD127.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
AF700
Unmodified
Mouse IgG1,κ
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD127 (IL-7Rα, IL7R) is the IL-7 receptor α-chain and a key immune molecule for maintaining T-cell survival, development, and memory formation. It is highly expressed on naive and memory T cells but expressed at low levels on regulatory T cells (Tregs); therefore, it is widely used in T-cell subset identification, immune monitoring, and research into tumor immunology, infection immunology, and autoimmune diseases.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Secreted
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Isoforms & Post-Translational Modification
CD127 has 4 isomers: P16871-1: 51579 Da (predicted); P16871-2: 34018 Da (predicted); P16871-3: 29936 Da (predicted); P16871-4: 28722 Da (predicted).
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form;Ubiquitinated by MARCHF8; leading to lysosomal degradation -
Subunit
The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Interacts with CD53
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Synonyms
CD127,CD127-AF700,A019D5
Documentation
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