AID Antibody (YA10091)
(Synonyms: AID, AICDA, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, Cytidine aminohydrolase)AID Antibody (YA10091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AID.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:50-400 | 1:100-500 | 1-2μg per 100-500μg Total protein | 1:3000-8000 |
Product Details
AID Antibody (YA10091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AID.
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Host Rabbit
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 24 kDa
OMIM: 605258
A synthesized peptide derived from human AID.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
AID is a Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation[1][2][3][4][5].
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Subcellular Localization
Nucleus; Cytoplasm, cytosol
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Expression
Tissue_Specificity: Strongly expressed in lymph nodes and tonsils.
Induction: Negatively regulated by microRNA-155 (miR-155). -
Isoforms & Post-Translational Modification
AID has 2 isoforms, Q9GZX7-1: amino acid length is 198, molecular weight is 23954 Da (predicted); Q9GZX7-2: amino acid length is 188, molecular weight is 22614 Da (predicted).Ser-38 是主要的磷酸化位点，而 Thr-27 是次要磷酸化位点。磷酸化可调节其类别转换重组活性AID 存在 2 个异构体，Q9GZX7-1：氨基酸个数为 198 个，分子量为 23954 Da (预测)；Q9GZX7-2：氨基酸个数为 188 个，分子量为 22614 Da (预测)。Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity
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Subunit
Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA.
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SwissProt ID
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Synonyms
AID, AICDA, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, Cytidine aminohydrolase
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