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Cat. No.: HY-P82283

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ALAS2 Antibody (YA2028)

Name: ALAS2 Antibody (YA2028)
Brand: MedChemExpress
SKU: HY-P82283
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E; SIDBA1)

ALAS2 Antibody (YA2028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALAS2.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IP
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IP IP: Immunoprecipitation
Dilution Ratio	1:500-1:1000	1:20-1:50

Product Details

Description

ALAS2 Antibody (YA2028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALAS2.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 65 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 65 kDa

Species Reactivity Database

Entrez Gene: 212 Human ; 11656 Mouse ; 25748 Rat

SwissProt: P22557 Human ; P08680 Mouse ; Q63147 Rat

OMIM: 300751 Human

Immunogen

A synthetic peptide of human ALAS2 aa568-580.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

ALAS2 catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Contributes significantly to heme formation during erythropoiesis; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 75-85% of isoform 1 activity; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 65-75% of isoform 1 activity^[1]^[2]^[3]^[4]^[5]^[6]^[7].
Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Mitochondrion inner membrane; Peripheral membrane protein
Expression

Tissue_specificity:Erythroid-specific; Erythroid-specific; Erythroid-specific; Erythroid-specific
Isoforms & Post-Translational Modification

P22557 has 4 isomers: P22557-1: 64633 Da (predicted); P22557-2: 60589 Da (predicted); P22557-3: 49395 Da (predicted); P22557-4: 63487 Da (predicted).
Subunit

Homodimer (PubMed:32499479). Interacts with SUCLA2 (PubMed:14643893, PubMed:32499479)
SwissProt ID

P22557
Gene ID

212 [NCBI]
Synonyms

ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E; SIDBA1
Research Field

Cardiovascular