APC-conjugated CD38 Antibody (HB-7)
(Synonyms: CD38,CD38-APC,HB-7)APC-conjugated CD38 Antibody (HB-7) is a Mouse-derived and APC conjugated monoclonal antibody, targeting to CD38.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD38 is a glycoprotein found on the surface of many immune cells, including T cells, B cells and natural killer cells. Additionally, CD38 has been shown to be a bifunctional enzyme expressing both ADP-ribosyl cyclase and cADPR hydrolase activities. The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability. In line with a role in inflammation, CD38 appears to also play a critical role in inflammatory processes during autoimmunity. Because of CD38 expression is highly upregulated on human plasma cells and especially on multiple myeloma cells.Targeting of CD38 is one of the most important and promising treatment avenues to help patients suffering from multiple myeloma.
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Expression
Tissue_specificity:It is highly expressed in the pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma, and neuroblastoma. -
Isoforms & Post-Translational Modification
CD38 has 2 isomers: P28907-1: 34328 Da (predicted); P28907-2: 13788 Da (predicted).
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Subunit
Homodimer
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Synonyms
CD38,CD38-APC,HB-7
Documentation
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