APC-conjugated CD8a Antibody (53-6.7)
(Synonyms: CD8a,CD8a-APC,53-6.7)APC-conjugated CD8a Antibody (53-6.7) is a Rat-derived and APC conjugated monoclonal antibody, targeting to CD8a.
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Host:
Rat
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Isotype:
Rat IgG2a,κ
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Application:
FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD8a (CD8α) is a key component of the CD8 co-receptor and is primarily expressed on cytotoxic CD8+ T cells. By enhancing TCR-MHC I signaling, it promotes T-cell activation, IFN-γ production, and granzyme/perforin-mediated cell killing; it is one of the most commonly used T-cell markers in tumor immunology, infection immunology, vaccine research, and CAR-T cell research.
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Expression
Tissue_specificity:CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation -
Isoforms & Post-Translational Modification
CD8a has 3 isomers: P01732-1: 25729 Da (predicted); P01732-2: 21585 Da (predicted); P01732-3: 30214 Da (predicted).
Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts;O-glycosylated;Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation -
Subunit
Forms disulfide-linked heterodimers with CD8B at the cell surface. Also forms homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes.
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Synonyms
CD8a,CD8a-APC,53-6.7
Documentation
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