APC-conjugated FOXP3 Antibody (206D)
(Synonyms: FOXP3,FOXP3-APC,206D)APC-conjugated FOXP3 Antibody (206D) is a Mouse-derived and APC conjugated monoclonal antibody, targeting to FOXP3.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
FOXP3, so called scurfin, belongs to the forkhead box protein P (FOXP) family. FOXP3 is critically involved in differentiation and function of regulatory T cells or CD4+/CD25+ regulatory T (Treg) cells for cancer immunotherapy. FOXP3 modulates Treg development and functions by immune evasion of tumor cells through imbalance of immunoediting and immunosurveillance in some cancers. FOXP3 is associated with IL-17, RUNX1, STAT3, NF-κB, FOXO3 and other cofactors such as EOS (Ikzf4), interferon regulatory factor 4 (IRF4), special AT-rich sequence-binding protein-1 (SATB1) and GATA1.
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Expression
Induction: Down-regulated in regulatory T-cells (Treg) during inflammation. Up-regulated by FOXO3
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Isoforms & Post-Translational Modification
FOXP3 has four isomers: Q9BZS1-1: 47244 Da (predicted); Q9BZS1-2: 43410 Da (predicted); Q9BZS1-3: 49843 Da (predicted); Q9BZS1-4: 44407 Da (predicted).
Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. -
Subunit
Homodimer
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Synonyms
FOXP3,FOXP3-APC,206D
Documentation
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