APC-Cy7-conjugated CD3 Antibody (17A2)
(Synonyms: CD3,CD3-APC-Cy7,17A2)APC-Cy7-conjugated CD3 Antibody (17A2) is a Rat-derived and APC-Cy7 conjugated monoclonal antibody, targeting to CD3.
-
Host:
Rat
-
Isotype:
Rat IgG2b,κ
-
Application:
FC
-
Reactivity :
Mouse
-
Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
-
Conjugation:
APC-Cy7
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
-
Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells) . It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
-
Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Peroxisome
-
Expression
Tissue_specificity:Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells -
Isoforms & Post-Translational Modification
CD3 has 3 isomers: P20138-1: 39825 Da (predicted); P20138-2: 33890 Da (predicted); P20138-3: 25293 Da (predicted).
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition;Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent -
Subunit
Homodimer; disulfide-linked. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
-
Synonyms
CD3,CD3-APC-Cy7,17A2
Documentation
Powered by Bioz
