ASB8 Antibody (YA8264)(PBS only)
(Synonyms: PP14212)ASB8 Antibody (YA8264) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ASB8.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
ASB8 Antibody (YA8264) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ASB8.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 31.5 kDa
Full length human recombinant protein of human ASB8 produced in E.coli.
Affinity purified
Non-conjugated
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ASB8 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation[1].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas -
Isoforms & Post-Translational Modification
Q9H765: 288 amino acids, molecular weight 31642 Da.
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Subunit
Interacts with TBK1; this interaction promotes TBK1 proteasomal degradation
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SwissProt ID
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Synonyms
PP14212
Documentation
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