Aurora C Antibody (YA7447)

Aurora kinase C (AURKC) is a serine/threonine kinase that functions predominantly in germ cells and plays a central role in meiotic chromosome segregation, spindle organization, and faithful progression through meiosis I and meiosis II^[1]. AURKC acts as a component of the chromosomal passenger complex (CPC) through association with inner centromere protein (INCENP) and related CPC proteins, thereby regulating chromosome dynamics during cell division^[2][3]. Mechanistically, CPC-associated Aurora kinases coordinate chromosome alignment, kinetochore function, and cytokinetic events that are required for accurate chromosome inheritance^[4][5]. In meiotic systems, accumulating evidence indicates that AURKC possesses functions that are distinct from those of Aurora kinase B (AURKB), contributing to specialized regulation of chromosome behavior in oocytes and spermatocytes^[1][6]. This functional specialization is particularly important because chromosome segregation errors during meiosis can lead to aneuploidy and reproductive defects^[1]. In disease-relevant settings, mutations in AURKC have been linked to abnormal spermatogenesis and male infertility, highlighting the biological significance of AURKC-dependent meiotic regulation^[1]. Compared with the related isoforms AURKA and AURKB, AURKC exhibits predominant germ-cell expression and participates preferentially in meiotic CPC functions rather than the canonical mitotic roles associated with AURKA or AURKB^[1][6]. For experimental applications, AURKC is frequently investigated through genetic depletion, mutation analysis, and CPC-based mechanistic studies to define kinase-dependent control of chromosome segregation and cytokinesis^[1][2][3].