BBS4 Antibody (YA10074)
(Synonyms: WW domain-binding protein 2; WBP-2)BBS4 Antibody (YA10074) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to BBS4.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
BBS4 Antibody (YA10074) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to BBS4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 58 kDa
Purified recombinant protein of human BBS4.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BBS4 is a The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, cilium membrane; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite; Cell projection, cilium, flagellum; Cell projection, cilium
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Expression
Tissue_Specificity: Ubiquitously expressed. The highest level of expression is found in the kidney. -
Isoforms & Post-Translational Modification
BBS4 has 3 isoforms, Q96RK4-1: amino acid length is 519, molecular weight is 58282 Da (predicted); Q96RK4-2: amino acid length is 527, molecular weight is 59084 Da (predicted); Q96RK4-3: amino acid length is 347, molecular weight is 38282 Da (predicted).
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Subunit
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
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SwissProt ID
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Synonyms
WW domain-binding protein 2; WBP-2
Documentation
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