beta 2 Microglobulin Antibody (YA934)
(Synonyms: B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p)beta 2 Microglobulin Antibody (YA934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to beta 2 Microglobulin.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:10000 |
Product Details
beta 2 Microglobulin Antibody (YA934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to beta 2 Microglobulin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 14 kDa
Purified recombinant human β2-microglobulin protein expressed in E.coli.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
beta 2 Microglobulin component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation[1].
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Subcellular Localization
Secreted; Cell surface
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Subunit
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen
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SwissProt ID
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Synonyms
B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p
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Research Field
Cardiovascular
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