2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. beta 2 Microglobulin Antibody (YA934)

beta 2 Microglobulin Antibody (YA934)

Cat. No.: HY-P81260
User Guide for Antibodies Technical Support

beta 2 Microglobulin Antibody (YA934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to beta 2 Microglobulin.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
50 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
100 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

beta 2 Microglobulin Antibody (YA934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to beta 2 Microglobulin.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 14 kDa;
Observed band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant human β2-microglobulin protein expressed in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG2b  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)
Subcellular Localization：Secreted; Cell surface
Subunit：Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen
Database

Entrez Gene: 567 Human

SwissProt: P61769 Human

OMIM: 241600 Human

Research Field

Cardiovascular
Synonyms
B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p
Documentation
User Guide for Antibodies (1077 KB)

beta 2 Microglobulin Antibody (YA934) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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beta 2 Microglobulin Antibody (YA934)
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