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CCDC93 Antibody (YA8685)(PBS only)

(Synonyms: FLJ10996; FLJ25197; MGC13033)

CCDC93 Antibody (YA8685) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCDC93.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Dog, Monkey, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CCDC93 Antibody (YA8685)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

CCDC93 Antibody (YA8685) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCDC93.

  • Host Mouse
  • Species Reactivity
    Human, Dog, Monkey, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 73 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 293-631 of human CCDC93 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CCDC93 component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C |(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface[1][2][3][4].

  • Subcellular Localization

    Early endosome

  • Isoforms & Post-Translational Modification

    Q567U6: 631 amino acids, molecular weight 73198 Da.

  • Subunit

    Component of the commander complex consisting of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129, PubMed:25355947, PubMed:28892079)

  • SwissProt ID

    Q567U6

  • Synonyms

    FLJ10996; FLJ25197; MGC13033

CCDC93 Antibody (YA8685)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CCDC93 Antibody (YA8685)(PBS only) Product Image