CD105 Antibody (YA6398)

Cat. No.: HY-P86706: Fiche technique User Guide for Antibodies
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Technical Support

CD105 Antibody (YA6398) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD105.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

CD105 Antibody (YA6398) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD105.

Host

Rabbit

Clonality

Monoclonal

Masse moléculaire

Predicted band size: 70 kDa

Species Reactivity

Human

SwissProt ID

P17813

Gene ID

2022 [NCBI]

Immunogen

Recombinant human CD105 Protein aa 26-586/658

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000

Pureté	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529)

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830)

Isoforms & Post-Translational Modification：P17813 has two isomers: P17813-1: 70578 Da (predicted); P17813-2: 67542 Da (predicted).

Subunit：Homodimer; disulfide-linked (PubMed:1326540, PubMed:21737454, PubMed:22347366, PubMed:28564608, PubMed:8370410)

Synonyms

END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen; EGLN_HUMAN; AI528660; AI662476; S-endoglin; SN6.

Documentation

User Guide for Antibodies (1077 KB)