CEP68 Antibody (YA8611)
(Synonyms: KIAA0582)CEP68 Antibody (YA8611) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEP68.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
CEP68 Antibody (YA8611) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEP68.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Full length human recombinant protein of human CEP68 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CEP68 is involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation[1][2][3][4].
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Isoforms & Post-Translational Modification
Q76N32 has two isomers: Q76N32-1: 81102 Da (predicted); Q76N32-2: 67040 Da (predicted).
Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564)丨Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25503564, PubMed:25704143) -
Subunit
Interacts with CNTLN; the interaction recruits CEP68 to the centrosome (PubMed:24554434)
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SwissProt ID
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Synonyms
KIAA0582
Documentation
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