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Cat. No.: HY-P86839

Ceruloplasmin Antibody (YA6532)

Name: Ceruloplasmin Antibody (YA6532)
Brand: MedChemExpress
SKU: HY-P86839
Availability: PreOrder

(Synonyms: CERU_HUMAN antibody; Ceruloplasmin antibody; CP 2 antibody; CP antibody; CP2 antibody; Ferroxidase antibody; )

Ceruloplasmin Antibody (YA6532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ceruloplasmin.

For research use only. We do not sell to patients.

Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot
Dilution Ratio	1:1000

Description

Ceruloplasmin Antibody (YA6532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ceruloplasmin.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Rat Predicted Reactivity: Human

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 140 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 122 kDa

Immunogen

Synthetic peptide within human Ceruloplasmin aa 401-450/1,065.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Ceruloplasmin multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis^[1].
Subcellular Localization

Secreted
Expression

Tissue_Specificity: Synthesized in liver and secreted into the plasma. Also choroid plexus, yolk sac, placenta, and testis; not in stomach and small intestine. Fetal lung and liver
Induction: By inflammation
Subunit

Found in a complex with MPO and LTF; interacts directly with MPO and LTF, which allows Fe(3+) incorporation into LTF, activation of CP ferroxidase activity and protection of CP antioxidant properties by MPO
SwissProt ID

P13635
Synonyms

CERU_HUMAN antibody; Ceruloplasmin antibody; CP 2 antibody; CP antibody; CP2 antibody; Ferroxidase antibody;