Ceruloplasmin Antibody (YA6532)

Cat. No.: HY-P86839: Data Sheet User Guide for Antibodies
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Ceruloplasmin Antibody (YA6532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ceruloplasmin.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Ceruloplasmin Antibody (YA6532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ceruloplasmin.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 122 kDa;

Observed band size: 140 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Rat Predicted Reactivity: Human

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

P13635

Gene ID

Immunogen

Synthetic peptide within human Ceruloplasmin aa 401-450/1,065.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (PubMed:14707133). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (By similarity)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Synthesized in liver and secreted into the plasma. Also choroid plexus, yolk sac, placenta, and testis; not in stomach and small intestine. Fetal lung and liver
Induction: By inflammation

Subunit：Found in a complex with MPO and LTF; interacts directly with MPO and LTF, which allows Fe(3+) incorporation into LTF, activation of CP ferroxidase activity and protection of CP antioxidant properties by MPO

Synonyms

CERU_HUMAN antibody; Ceruloplasmin antibody; CP 2 antibody; CP antibody; CP2 antibody; Ferroxidase antibody;

Documentation

User Guide for Antibodies (1077 KB)