CFI Antibody (YA8110)
(Synonyms: AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF)CFI Antibody (YA8110) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CFI.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
CFI Antibody (YA8110) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CFI.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 63.4 kDa
Human recombinant protein fragment corresponding to amino acids 340-583 of human CFI produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CFI is a Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization[1][2][3][4][5][6].
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Subcellular Localization
Secreted, extracellular space,Secreted
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Expression
Tissue_Specificity: Expressed in the liver by hepatocytes (PubMed:6327681). Also present in other cells such as monocytes, fibroblasts or keratinocytes (PubMed:17320177, PubMed:6444659) -
Isoforms & Post-Translational Modification
P05156: 583 amino acids, molecular weight 65750 Da.
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Subunit
Heterodimer of a light and heavy chains; disulfide-linked
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SwissProt ID
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Synonyms
AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Documentation
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