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CHCHD3 Antibody (YA7878)(PBS only)

(Synonyms: MINOS3; PPP1R22)

CHCHD3 Antibody (YA7878) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHCHD3.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CHCHD3 Antibody (YA7878)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-2000 1:150-500

Product Details

Description

CHCHD3 Antibody (YA7878) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHCHD3.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 26 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 2-227 of human CHCHD3 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CHCHD3 component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription[1][2][3][4].

  • Subcellular Localization

    Mitochondrion inner membrane,Cytoplasm,Nucleus,Mitochondrion

  • Expression


    Tissue_Specificity: Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue

  • Isoforms & Post-Translational Modification

    Q9NX63: 227 amino acids, molecular weight 26152 Da.

  • Subunit

    Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101)

  • SwissProt ID

    Q9NX63

  • Synonyms

    MINOS3; PPP1R22

CHCHD3 Antibody (YA7878)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CHCHD3 Antibody (YA7878)(PBS only) Product Image