CHCHD3 Antibody (YA7878)(PBS only)

Cat. No.: HY-P88194A: Data Sheet User Guide for Antibodies
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CHCHD3 Antibody (YA7878) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHCHD3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CHCHD3 Antibody (YA7878) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHCHD3.

Host

Mouse

Molecular Weight

Predicted band size: 26 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NX63

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-227 of human CHCHD3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091)

Subcellular Localization：Mitochondrion inner membrane,Cytoplasm,Nucleus,Mitochondrion

Expression：
Tissue_Specificity: Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue

Isoforms & Post-Translational Modification：Q9NX63: 227 amino acids, molecular weight 26152 Da.

Subunit：Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101)

Synonyms

MINOS3; PPP1R22

Documentation

User Guide for Antibodies (1077 KB)