CHP Antibody (YA8275)(PBS only)

Cat. No.: HY-P88591A: Data Sheet User Guide for Antibodies
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CHP Antibody (YA8275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CHP.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CHP Antibody (YA8275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CHP.

Host

Mouse

Molecular Weight

Predicted band size: 22.3 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q99653

Immunogen

Full length human recombinant protein of human CHP produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner

Subcellular Localization：Nucleus,Cytoplasm,Cytoplasm, cytoskeleton,Endomembrane system,Endoplasmic reticulum-Golgi intermediate compartment,Endoplasmic reticulum,Cell membrane,Membrane

Expression：
Tissue_Specificity: Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen

Isoforms & Post-Translational Modification：Q99653: 195 amino acids, molecular weight 22456 Da.

Subunit：Monomer

Synonyms

CHP; p22; p24; Sid470p; SLC9A1BP

Documentation

User Guide for Antibodies (1077 KB)