Cip4 Antibody (YA7278)

Cat. No.: HY-P87594: Data Sheet User Guide for Antibodies
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Cip4 Antibody (YA7278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cip4.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

Cip4 Antibody (YA7278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cip4.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 68 kDa;

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q15642

Immunogen

A synthesized peptide derived from human TRIP10

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200
IHC-F IHC-F: Immunohistochemistry-Frozen	1:100-200
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:100-200

Sensitivity	Endogenous	Purity	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL

Subcellular Localization：Cytoplasm, cytoskeleton,Cytoplasm, cell cortex,Lysosome,Golgi apparatus,Cell membrane,Cell projection, phagocytic cup,Cytoplasm, perinuclear region

Expression：
Tissue_Specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea
Induction: Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation

Isoforms & Post-Translational Modification：Q15642 has 5 isomers: Q15642-1: 68352 Da (predicted); Q15642-2: 62592 Da (predicted); Q15642-3: 67603 Da (predicted); Q15642-4: 52700 Da (predicted); Q15642-5: 39583 Da (predicted).
Tyrosine phosphorylated

Subunit：Interacts specifically with GTP-bound RHOQ

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/a498-cell.html [Content Brief]