CITED1 Antibody (YA8272)
(Synonyms: MSG1)CITED1 Antibody (YA8272) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CITED1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
CITED1 Antibody (YA8272) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CITED1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 19.7 kDa
Full length human recombinant protein of human CITED1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CITED1 transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner
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Subcellular Localization
Nucleus,Cytoplasm
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Expression
Tissue_Specificity: Expressed only in melanocytes and testis
Induction: Up-regulated by GPR39 in neuronal cells -
Isoforms & Post-Translational Modification
Q99966 has two isomers: Q99966-1: 19896 Da (predicted); Q99966-2: 22613 Da (predicted).
Phosphorylated -
Subunit
Interacts (via C-terminus) with CREBBP
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SwissProt ID
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Synonyms
MSG1
Documentation
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