CLCA1 Antibody (YA7771)(PBS only)

Cat. No.: HY-P88087A: Data Sheet User Guide for Antibodies
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CLCA1 Antibody (YA7771) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLCA1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CLCA1 Antibody (YA7771) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLCA1.

Host

Mouse

Species Reactivity

Human

SwissProt ID

A8K7I4

Immunogen

Human recombinant protein fragment corresponding to amino acids 344-412 of human CLCA1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC

Subcellular Localization：Secreted, extracellular space,Cell membrane

Expression：
Tissue_Specificity: Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in
Induction: By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa

Isoforms & Post-Translational Modification：A8K7I4: 914 amino acids, molecular weight 100226 Da.

Synonyms

CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1; hCLCA1

Documentation

User Guide for Antibodies (1077 KB)