CLPTM1 Antibody (YA2521)
(Synonyms: Cleft lip and palate transmembrane protein 1)CLPTM1 Antibody (YA2521) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLPTM1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
CLPTM1 Antibody (YA2521) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLPTM1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 76 kDa
A synthetic peptide of human CLPTM1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLPTM1 is involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development[1].
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Subcellular Localization
Membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Widely expressed -
Isoforms & Post-Translational Modification
O96005 has 3 isomers: O96005-1: 76097 Da (predicted); O96005-3: 65597 Da (predicted); O96005-4: 75178 Da (predicted).
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SwissProt ID
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Synonyms
Cleft lip and palate transmembrane protein 1
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Research Field
Cell Biology
Documentation
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