COX4NB Antibody (YA8151)

Cat. No.: HY-P88467: Data Sheet User Guide for Antibodies
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COX4NB Antibody (YA8151) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to COX4NB.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

COX4NB Antibody (YA8151) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to COX4NB.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 23.6 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O43402

Immunogen

Full length human recombinant protein of human COX4NB produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)

Subcellular Localization：Endoplasmic reticulum membrane

Expression：
Tissue_Specificity: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta

Isoforms & Post-Translational Modification：O43402 has two isomers: O43402-1: 23773 Da (predicted); O43402-2: 13726 Da (predicted).

Subunit：Component of the ER membrane protein complex (EMC) (PubMed:22119785, PubMed:29242231)

Synonyms

C16orf2; C16orf4; COX4NB; FAM158B; NOC4

Documentation

User Guide for Antibodies (1077 KB)