Cytochrome C Oxidase subunit Vic Antibody
(Synonyms: Cytochrome c oxidase subunit 6C, Cytochrome c oxidase polypeptide VIc, COX6C)Cytochrome C Oxidase subunit Vic Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to COX6C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:100 |
Product Details
Cytochrome C Oxidase subunit Vic Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to COX6C.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 12 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 9 kDa
A synthetic peptide of human Cytochrome C Oxidase subunit Vic
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
COX6C is a Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
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Subcellular Localization
Mitochondrion inner membrane
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Isoforms & Post-Translational Modification
COX6C has an amino acid length of 75, molecular weight is 8781 Da.
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Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
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SwissProt ID
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Synonyms
Cytochrome c oxidase subunit 6C, Cytochrome c oxidase polypeptide VIc, COX6C
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