Cyclin Y Antibody
(Synonyms: C10orf9, CBCP1, CFP1, CCNY, Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X)Cyclin Y Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Cyclin Y.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Cyclin Y Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Cyclin Y.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 39 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
Synthetic peptide corresponding to the Central region of human Cyclin Y.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cyclin Y is a Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Widely expressed. -
Isoforms & Post-Translational Modification
Cyclin Y has 3 isoforms, Q8ND76-1: amino acid length is 341, molecular weight is 39337 Da (predicted); Q8ND76-2: amino acid length is 316, molecular weight is 36504 Da (predicted); Q8ND76-3: amino acid length is 287, molecular weight is 33245 Da (predicted).Ubiquitinated; leading to its degradation
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Subunit
Found in a complex with CAPRIN2, LRP6 and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus.
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SwissProt ID
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Synonyms
C10orf9, CBCP1, CFP1, CCNY, Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X
Documentation
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