DBNL Antibody (YA8640)

Cat. No.: HY-P88956: Fiche technique User Guide for Antibodies
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DBNL Antibody (YA8640) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DBNL.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

DBNL Antibody (YA8640) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DBNL.

Host

Mouse

Clonality

Monoclonal

Masse moléculaire

Predicted band size: 48.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9UJU6

Immunogen

Full length human recombinant protein of human DBNL produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Pureté	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes

Subcellular Localization：Cytoplasm, cytoskeleton,Cell projection, lamellipodium,Cell projection, ruffle,Cytoplasm, cell cortex,Cytoplasm, cytosol,Synapse,Perikaryon,Cell projection, neuron projection,Cell membrane,Cytoplasmic vesicle, clathrin-coated vesicle membrane,Golgi apparatus membrane,Cell projection, podosome,Early endosome,Cell projection, dendrite,Postsynaptic density

Isoforms & Post-Translational Modification：Q9UJU6 has 6 isomers: Q9UJU6-1: 48207 Da (predicted); Q9UJU6-2: 48294 Da (predicted); Q9UJU6-3: 49042 Da (predicted); Q9UJU6-4: 37959 Da (predicted); Q9UJU6-5: 37101 Da (predicted); Q9UJU6-6: 43041 Da (predicted).
Degraded by caspases during apoptosis

Subunit：Interacts with SHANK2, SHANK3 and SYN1

Synonyms

ABP1; HIP-55; HIP55; SH3P7

Documentation

User Guide for Antibodies (1077 KB)